Determination of an Initial Stage of the Bone Tissue Ingrowth Into Titanium Matrix by Cell Adhesion Model

For achieving early intervention treatment to help patients delay or avoid joint replacement surgery, a personalized scaffold should be designed coupling the effects of mechanical, fluid chemical, and biological factors on tissue regeneration, which results in time- cost-consuming trial-and-error analyses investigate vivo test related experimental tests. To optimize mechanical material properties predict osteogenesis cartilage regeneration for clinical trial, simulation approach is developed design, composed volume model simulating bone marrow filling process air, as well discrete phase cell impingement tracking movement during fillings. The treated non-Newtonian fluid, rather than Newtonian because its viscoelastic property. indicated that biofunctional bionic with dense layer prevent flow synovia into trabecular area guarantee good leads high-accuracy tests sheep . This not only predicts final bioperformance but also could structure materials by their biochemical, biological, biomechanical properties.